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, at 24-hours post-dosing were 14 9, 16 10, 24 14, 27 22 and 27 20 reduction in exercise heart rate for doses of 50, 100, 200, 300 and 400 mg toprol-xl once a day, respectively.

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Toprol-xl is indicated for the treatment of stable, symptomatic nyha class ii or iii heart failure of ischemic, hypertensive, or cardiomyopathic origin.

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