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Anticholinergic agents may affect gastrointestinal absorption of various drugs, such as slowly dissolving dosage forms of digoxin; increased serum digoxin concentrations may result.

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Compounds which have been tested in man have included propanolol, digoxin, glibenclamide, warfarin, theophylline and phenazone and no meaningful interactions were found.

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Lim jacob assessed the serum and urine electrolyte concentrations of 10 hf patients receiving diuretics and digoxin, and found that five patients had magnesium deficiency, four of whom showed clinical symptoms of digoxin intoxication 21 .

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