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Selegiline is used to help control the symptoms of parkinson s disease pd; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance in people who are taking levodopa and carbidopa combination sinemet .

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To combat unresponsiveness to pd medication, a controlled release formulation of sinemet, sinemet cr, was developed.

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Standard drugs for parkinson s disease, other than levodopa without a decarboxylase inhibitor, may be used concomitantly while sinemet cr is being administered, although their dosage may have to be adjusted.

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Postural hypotension can occur when sinemet is added to the treatment of patients already receiving antihypertensive drugs.

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