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Drinking alcohol, especially on a daily basis, may enhance the risk of isoniazid-associated hepatitis.

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myambutol-inh isoniazid is contraindicated in patients who develop severe hypersensitivity reactions, including drug-induced hepatitis; previous isoniazid-associated hepatic injury; severe adverse reactions to myambutol-inh isoniazid such as drug fever, chills, arthritis; and acute liver disease of any etiology.

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if an unknown amount of isoniazid is ingested, consider an initial dose of 5 grams of pyridoxine given over 30 to 60 minutes in adults or 80 mg kg of pyridoxine in children.

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