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The randomized aldactone evaluation study rales was a multinational, double-blind study in patients with an ejection fraction of 35 , a history of new york heart association nyha class iv heart failure within 6 months, and class iii iv heart failure at the time of randomization.

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any other diuretics, such as amiloride midamor , bumetanide bumex , furosemide lasix , hydrochlorothiazide hctz, hydrodiuril, hyzaar, lopressor hct, vasoretic, zestoretic , spironolactone aldactone , torsemide demadex , and others;.

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because of the additive effect of aldactone when administered concurrently with such diuretics, an enhanced diuresis usually begins on the first day of combined treatment; combined therapy is indicated when more rapid diuresis is desired.

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because of tumor formation in experimental animals, use in pregnancy should be avoided unless the benefits outweigh the potential risks to the fetus; women who are breastfeeding are advised not to use aldactone.

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