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the majority of case reports historically have not included measurements of metformin levels because this is not a commonly available lab test.

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while the advanced setting can provide a sufficient event rate, there is evidence to suggest that metformin requires long-term use to exert its anti-cancer effect 78 , and therefore, patients with established cancer with more limited prognoses may not be able to receive metformin long enough for a therapeutic benefit to emerge.

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decreases in hemoglobin and hematocrit in the metformin group occurred during the first year following randomization, with no further changes observed over time.


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