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Depression, suicide, attempted suicide and suicidal ideation have been reported in the postmarketing experience with naltrexone hydrochloride used in the treatment of opioid dependence.

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because of this, naltrexone is sometimes given to patients who must take opioid pain relievers on a regular basis because of severe or chronic pain.

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a study in recreational opioid-users indicated that morphine and naltrexone injected in the 25 1 ratio duplicating the ratio of the formulation found ms-snt reduced morphine-induced euphoric effects vs intravenous iv morphine alone.

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interestingly, a dopaminergic link in the suppression of ethanol self-administration by naltrexone was reflected also in the specific behavioral changes induced by the drug.

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