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to make sure digoxin is safe for you, tell your doctor if you have a serious heart condition such as sick sinus syndrome or av block unless you have a pacemaker ; a recent history of heart attack; wolff-parkinson-white syndrome udden fast heartbeats ; kidney disease; a thyroid disorder; an electrolyte imbalance such as low levels of calcium, potassium, or magnesium in your blood ; if you are malnourished or have recently been sick with vomiting or diarrhea; or if you take a diuretic water pill , or use steroid medicine.

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potential pharmacokinetic interactions were assessed in clinical pharmacokinetic studies phenytoin, valproate, oral contraceptive, digoxin, warfarin, probenecid and through pharmacokinetic screening in the placebo controlled clinical studies in epilepsy patients.

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the two drugs differ in that digoxin has an additional hydroxyl group at the c-3 position on the b-ring adjacent to the pentane .

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in clinical trials, amlodipine has been safely administered with thiazide diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs.

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