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Stop metformin at the time of, or prior to, an iodinated contrast imaging procedure in patients with an egfr between 30 and 60 ml min 1.

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food decreases the rate and extent of metformin absorption, as shown by a 40 lower mean c max , a 25 lower auc, and a 35-minute prolongation of t max following administration of a single 850 mg tablet of metformin with food, compared to the same tablet strength administered fasting.

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morphine was injected subcutaneously 10 mg kg once a day for 7 days; metformin 200 mg kg was administered intraperitoneally daily 15 min before each morphine injection.


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